In recent years, there’s been growing awareness of the role genetics plays in how our bodies process nutrients—particularly the B vitamins involved in energy, brain health, and detoxification. So when we say the Mighty Kids and Adult Multi contain methylated B vitamins, some parents naturally ask:
“What if my child is sensitive to methylation?”
“Do I need to test their genes first?”
Here’s what we want you to know:
You don’t need genetic testing to take our formulas safely.
We’ve already done the work to make them effective and gentle enough for everyday use.
Let’s explore the science—so you can feel fully informed and confident.
What Are Methylated B Vitamins?
Methylated B vitamins are the active forms your body uses directly—no conversion needed.
• 5-MTHF → Active folate
• Methylcobalamin → Active B12
• P-5-P → Active B6
These forms occur naturally in food and are essential for:
• DNA repair
• Neurotransmitter production (like serotonin and dopamine)
• Detoxification (methylation is how your body clears toxins)
• Immune balance and energy metabolism
Why Some People Struggle with Synthetic Forms
Many supplements still use folic acid (synthetic B9) and cyanocobalamin (synthetic B12), which must be converted into active forms before the body can use them.
But here’s the problem:
About 60% of the population has one or more MTHFR gene variants that reduce this conversion process—sometimes by up to 70%. This can lead to unmet nutritional needs, even in people eating a healthy diet or taking basic multivitamins. Some may accumulate unmetabolized folic acid, which can block folate receptors and interfere with normal function.
This is one of the key reasons we never use folic acid or synthetic B12 in any of our formulas.
Read this blog post for more on MTHFR.
What About Sensitivity to Methylated Vitamins?
A small percentage of people may feel overstimulated by high doses of methylated B vitamins—typically adults with:
• COMT slow variants → slower breakdown of dopamine, leading to jitteriness or mood swings
• MAO-A slow variants → affects serotonin and stress response
• Underlying histamine intolerance or poor detox → makes it harder to process increased methylation activity
These effects are usually temporary and dose-dependent.
How We Designed the Mighty Kids Multivitamins to Be Safe & Effective
For Kids- Mighty Kids Mini Multi:
• Uses low, balanced doses of methylated B vitamins
• Gentle enough for daily use, even in children with suspected MTHFR mutations
• Recommended alongside Mighty Kids magnesium to help buffer methylation and support calm nervous system function
• No synthetic folic acid or inactive B12—ever
Many parents report benefits such as fewer emotional ups and downs, stable energy, better focus, and fewer infections.
For adults/teens or kids using smaller age appropriate servings- Mighty Multi:
• Uses higher, functional doses of methylated Bs to support common adult needs:
• Stress recovery
• Hormonal regulation
• Liver detox
• Cognitive support
• Designed to nourish those who may be depleted from years of stress, poor sleep, or postnatal nutrient loss
Solutions for Sensitive Individuals:
• Start with half a dose
• Take with food
• Consider alternating days
• Pair with magnesium if prone to overstimulation
Do You Need to Test Your Genes First? No.
While gene testing can be helpful in certain therapeutic cases, it’s not a requirement for choosing a high-quality multivitamin.
We designed the Mighty Multis to be safe and beneficial across the spectrum—with smart doses and active ingredients that support the majority of bodies without causing overwhelm. We always recommend:
• Starting slow if you’re unsure
• Listening to your body
• Giving your child a day off the multi if they seem overstimulated, monitor behaviour and reintroduce for further monitoring.
But in nearly all cases, methylated B vitamins are more helpful than harmful, especially in well-designed formulas like ours.
Why We’re So Passionate About This
This is about real biology.
Our bodies are exposed to more stress, toxins, and nutritional gaps than ever before. And methylated B vitamins are one of the most effective tools we have to support resilience, clarity, and well-being.
We believe in giving your family:
• Nutrients they can actually absorb (read about our liposomal technology), in doses that make a difference, and in forms that respect real-life biochemistry
And we’re proud to offer that in both our Mighty Kids Mini Multi and the Mighty Multi!
https://mightykidssupplements.co.uk/product/multivitamin/
https://mightykidssupplements.co.uk/product/mighty-multivitamin/
